Genetics & Mapping  
The first part of the program, Genetics, takes undergraduates through the basic principles of Mendelian genetics, monohybrid and dihybrid crosses, and the derivation of the resultant phenotypes. The basics of meiosis are outlined and how this relates to the generation of random assortment. Variations on the classic 9:3:3:1 ratios are included to show how different phenotypic ratios are derived under conditions of gene interaction. The second part of the program, Mapping, is a short tutorial on how to perform three factor crosses, determine gene order, distance and the effects of interference.
Submitted: Sep 16, 2000
Allows to investigate the process of adaptation by natural selection by manipulating various parameters of a bird species, such as initial mean beak size, variability, heritability, and population size, and various parameters of the environment such as precipitation and island size. This lab can be used to investigate evolutionary principles such as directional, disruptive and balancing selection, the dependence of natural selection on the variability and heritability of a trait, founder effects, genetic drift, and extinction.
Submitted: Nov 01, 2000
In this lab students use pedigree analysis to study the inheritance of genes for human genetic disorders and RFLP analysis to study recombination in humans. Using RFLPs as genetic markers, students search a simulated pedigree database to obtain recombination data that allows them to determine the location of human genes on chromosomes.
Submitted: Nov 01, 2000
Allows students to create simple RNA sequences and then translate these in a virtual "in vitro" cell-free system. From the proteins produced by the translation mix, students determine the characteristics of the genetic code and assign codons to amino acids. This lab was modeled after some of the original experiments used to determine the genetic code.
Submitted: Nov 01, 2000
Choosing Primers for Sequencing  
Information provided by the DNA sequencing facility at the University of Chicago Cancer Research Centre.
Submitted: Dec 02, 2000
Design of Primers for Automated Sequencing  
Guide to designing primers from the DNA sequencing core facility at the University of Michigan.
Submitted: Dec 02, 2000
DNA Sequencing Core  
The University of Michigan's DNA Sequencing Core provides U-M investigators access to automated DNA sequencing technology on a recharge basis. The Core owns two ABI Model 377XL DNA Sequencers, two Model 373XLs and a 373A on which samples are processed. Samples are typically processed in 2-3 days, and yield 300-700 nucleotides of high-quality DNA sequence data (better than 99% accuracy typ.; see documents below). The cost for this service is $16 per sample (one template, one primer), with various discounts available for larger numbers of samples and for members of certain Centers.
Submitted: Dec 01, 2000
GenScope Project  
GenScope is a learning environment that uses the computer to provide an alternative to text-based science education. It provides teachers and learners with a new tool that enables students to investigate scientific and mathematical concepts through direct manipulation and experimentation.
Submitted: Nov 05, 2000
In this laboratory, you will perform simulations of experiments designed to study factors that can lead to changes in genotype frequency in a population resulting in population genetic changes that influence the evolution of moths. By manipulating genetic and environmental parameters that influence the genetics of these moths, you will learn about important principles of population genetics and the factors that can affect population genetics for any species.
Submitted: Nov 01, 2000
Primer on Molecular Genetics  
This primer was prepared by Denise Casey (Human Genome Management Information System - Oak Ridge National Laboratory) for the 1991-92 DOE Human Genome Program Report.
Submitted: Nov 24, 2000

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