| Genetics & Mapping
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The first part of the program, Genetics, takes undergraduates through the basic principles of Mendelian genetics, monohybrid and dihybrid crosses, and the derivation of the resultant phenotypes. The basics of meiosis are outlined and how this relates to the generation of random assortment. Variations on the classic 9:3:3:1 ratios are included to show how different phenotypic ratios are derived under conditions of gene interaction. The second part of the program, Mapping, is a short tutorial on how to perform three factor crosses, determine gene order, distance and the effects of interference.
Submitted Sep 16, 2000
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| EvolutionLab
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Allows to investigate the process of adaptation by natural selection by manipulating various parameters of a bird species, such as initial mean beak size, variability, heritability, and population size, and various parameters of the environment such as precipitation and island size. This lab can be used to investigate evolutionary principles such as directional, disruptive and balancing selection, the dependence of natural selection on the variability and heritability of a trait, founder effects, genetic drift, and extinction.
Submitted Nov 01, 2000
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| Genetic Science Learning Center
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A joint project of the University of Utah Eccles Institute of Human Genetics, Museum of Natural History, and School of Medicine.
Submitted Nov 05, 2000
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| PedigreeLab
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In this lab students use pedigree analysis to study the inheritance of genes for human genetic disorders and RFLP analysis to study recombination in humans. Using RFLPs as genetic markers, students search a simulated pedigree database to obtain recombination data that allows them to determine the location of human genes on chromosomes.
Submitted Nov 01, 2000
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| FlyLab
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In this interactive lab students learn the principles of genetic inheritance by designing matings between female and male fruit flies carrying one or more genetic mutations. This lab can be used to demonstrate genetic principles such as dominant versus recessive traits, independent assortment, sex-linked inheritance, linkage and chromosome maps, and modifications to Mendelian ratios caused by lethal mutations and epistasis.
Submitted Nov 01, 2000
Updated Apr 30, 2008
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| HGMP-RC Introductory Molecular Biology Computing
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The aim of this course is to introduce Molecular Biologists to advanced methods of constructing gene model prediction programs. This course will provide practical training on how to use the appropriate programs for gene model prediction, and how to interpret program output.
Submitted Dec 09, 2000
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| TranslationLab
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Allows students to create simple RNA sequences and then translate these in a virtual "in vitro" cell-free system. From the proteins produced by the translation mix, students determine the characteristics of the genetic code and assign codons to amino acids. This lab was modeled after some of the original experiments used to determine the genetic code.
Submitted Nov 01, 2000
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| Choosing Primers for Sequencing
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Information provided by the DNA sequencing facility at the University of Chicago Cancer Research Centre.
Submitted Dec 02, 2000
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| Design of Primers for Automated Sequencing
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Guide to designing primers from the DNA sequencing core facility at the University of Michigan.
Submitted Dec 02, 2000
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| DNA Sequencing Core
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The University of Michigan's DNA Sequencing Core provides U-M investigators access to automated DNA sequencing technology on a recharge basis. The Core owns two ABI Model 377XL DNA Sequencers, two Model 373XLs and a 373A on which samples are processed. Samples are typically processed in 2-3 days, and yield 300-700 nucleotides of high-quality DNA sequence data (better than 99% accuracy typ.; see documents below). The cost for this service is $16 per sample (one template, one primer), with various discounts available for larger numbers of samples and for members of certain Centers.
Submitted Dec 01, 2000
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| GenScope Project
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GenScope is a learning environment that uses the computer to provide an alternative to text-based science education. It provides teachers and learners with a new tool that enables students to investigate scientific and mathematical concepts through direct manipulation and experimentation.
Submitted Nov 05, 2000
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| PopGenLab
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In this laboratory, you will perform simulations of experiments designed to study factors that can lead to changes in genotype frequency in a population resulting in population genetic changes that influence the evolution of moths. By manipulating genetic and environmental parameters that influence the genetics of these moths, you will learn about important principles of population genetics and the factors that can affect population genetics for any species.
Submitted Nov 01, 2000
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| Primer on Molecular Genetics
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This primer was prepared by Denise Casey (Human Genome Management Information System - Oak Ridge National Laboratory) for the 1991-92 DOE Human Genome Program Report.
Submitted Nov 24, 2000
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