Software

EffTox: Dose-finding based on efficacy and toxicity  
EffTox is software for implementing the phase I/II dose-finding methodology of Thall and Cook. This method uses efficacy and toxicity information to adaptively determine the best dose as the clinical trial progresses. Software for simulating and conducting clinical trials using EffTox is available for free download.
Submitted: Jun 08, 2005
ADMEWORKS ModelBuilder  
ADMEWORKS ModelBuilder is a tool for building mathematical models that can later be used for predicting various chemical and biological properties of compounds.
Submitted: Jan 31, 2005
ADME DB  
ADME DB is a database containing information on Human Cytochrome P450 metabolism, kinetics, transporter and structure. The information is organized by category (therapeutic area), drug name, enzyme, reaction, and type. The database includes about 11 000 entries, 5000 reactions, 3000 references and 6500 structures in mol format.
Submitted: Jan 31, 2005
Multc Lean: Phase II safety monitoring based on efficacy and toxicity  
Multc Lean is a simplified implementation of the Multc99 methodology of Thall, Simon, and Estey. This method monitors single-arm phase II studies, comparing experimental response and toxicity probabilities against historical standards.
Submitted: Jun 08, 2005
VelQuest Corporation  
VelQuest Corporation is aimed to develop and market innovative solutions solving unmet needs in technology-based operations in the pharmaceutical and related industries.
Submitted: Nov 12, 2000



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