| Carbohydrate-Active Enzymes
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This server describes the families of structurally-related catalytic and carbohydrate-binding modules (or functional domains) of enzymes that degrade, modify, or create glycosidic bonds.
Submitted Dec 02, 2000
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| 2-DE Database for Human Heart Proteins
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This is the two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) database for human heart proteins. It contains data on proteins identified on the 2-D PAGE maps of ventricle and atrium of human heart.
Submitted Dec 03, 2000
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| 2-DE Gel Protein Databases at Harefield
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On this pages you can peruse individual HSC-2DPAGE 2D-gel protein databases, search all HSC-2DPAGE 2D-gel protein databases, compare 2D-gel images using Flicker, or browse other 2D-gel protein databases available on the Web.
Submitted Dec 03, 2000
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| 3D ALI
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A database of aligned protein structures and related sequences.
Submitted Jan 05, 2001
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| A Library of Protein Family Cores
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Core structures computed from structural alignments of protein families. This library is useful for building models,
threading, and exploratory analysis. It is also a useful mechanism for summarizing variability in NMR structures.
Submitted Dec 02, 2000
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| A Protein Quaternary Structure File Server
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The Protein Quaternary Structure file server ( PQS ) is an internet resource that makes available coordinates for likely quaternary states for structures contained in the Brookhaven Protein Data Bank (PDB) that were determined by X-ray crystallography.
Submitted Oct 19, 2000
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| Biobase / Julio Celis Database
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The Danish Centre for Human Genome Research's 2-D PAGE Databases at the University of Aarhus, which are being developed for functional genome analysis in health and disease, contain data on proteins identified on various reference maps. You can display protein names and information on specific protein spots by clicking on the image in which you are interested. Also, you can search by protein name, keywords, Mr and pI or organelle or cellular component. Protein files contain extensive links to other databases (MEDLINE, GenBank, Swiss-Prot, PIR, PDB, OMIM, UniGene, GeneCards, etc.) or Web sites.
Submitted Dec 03, 2000
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| Chromatin Structure & Function Page
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This site is intended to disseminate information regarding the rapidly evolving and highly exciting field of chromatin structure, proteins that modify chromatin structure, and the effects that these modifications have on cell function.
Submitted Dec 02, 2000
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| CPHmodels
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The CPHmodels World Wide Web server predict protein structure using comparative (homology) modelling.
Submitted Dec 09, 2000
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| DbClustal
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Rapid and reliable global multiple alignments of protein sequences detected by database searches.
Submitted Dec 03, 2000
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| EF-Hand Calcium-Binding Proteins Data Library
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Information about the EF-hand calcium-binding protein family, including sequence, structure, and function data.
Submitted Nov 25, 2000
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| ESTHER
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This server is dedicated to the analysis of protein and nucleic acid sequences belonging to the superfamily of alpha/beta hydrolases homologous to cholinesterases.
Submitted Dec 02, 2000
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| FYVE Finger
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The FYVE finger is a novel zinc finger-like domain found in several proteins involved in membrane trafficing. The basic motif consists of 8 Cysteins, 4 of which are part of the core motif R+HHC+XCG (where '+' is a positively charged residue and 'X' is any aminoacid). This finger has only been observed as a single copy in each of the proteins and it has been shown to bind 2 zinc ions per finger. In this work, it was shown that the EEA1 (Early Endosome Associated protein 1) requires it's FYVE finger for endosomal localisation, - and most likely, the EEA1 FYVE finger is sufficient for endosome targeting of this protein. The FYVE fingers in other proteins may play similar roles.
Submitted Dec 02, 2000
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| GELLAB-II 2D Gel Analysis
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GELLAB-II is an integrated collection of programs for the analysis of 2D electrophoretic gels. Currently, it runs on UNIX systems. The display of gel images is available if the hardware supports a color display under X-windows. These programs were developed at the Image Processing Section in the National Cancer Institute.
Submitted Dec 03, 2000
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| High-Performance Heart
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Heart High-Performance 2-DE Database contains about 3300 proteins of ventricle resolved by large gels (23 cm x 30 cm x 0.075 cm). Proteins were detected by silver staining. 2-DE patterns were evaluated by the TopSpot software package.
Submitted Dec 03, 2000
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| HOX-Pro DataBase
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The HOX-Pro is aimed at 1) analysis and classification of regulatory and coding regions in diverse homeobox and related genes-controllers of invertebrate and vertebrate development; 2) comparative analysis of organisation of "hox-based" genetic networks for C.elegans, sea urchins, Drosophila and mammals; 3) analysis of phylogeny and evolution of homeobox genes and clusters.
Submitted Dec 02, 2000
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| Inteins
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Inteins are proteins inserted in-frame and translated together with their host proteins. This site mainly focuses on intein sequence motifs and evolution.
Submitted Dec 02, 2000
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| Joint Protein Structure Laboratory
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Homepage of JPSL, Joint Protein Structure Laboratory, Ludwig Institute for Cancer Research and The Walter and Eliza Hall Institute of Medical Research. Proteomic databases, techniques and methods, staff, publications and news and conferences.
Submitted Dec 03, 2000
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| Lipase Engineering Database
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This Internet database provides information on sequence and structure of lipases to facilitate protein engineering. We acknowledge your comments or contribution to this page: please send us information to be included in this database.
Submitted Dec 02, 2000
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| Majestix
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Parasite host cell interaction 2D-PAGE database at the Department of Medical Microbiology and Immunology of the University of Aarhus.
Submitted Dec 03, 2000
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| Make2ddb
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The Make2ddb package lets you easily create a 2-DE database on your Web server, with search functions, such as by accession number, by description, by author, and by clicking on a spot, similar to SWISS-2DPAGE.
Submitted Dec 03, 2000
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| Melanie 3
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Melanie 3 is the all-in-one solution for analyzing, annotating and querying your 2D gel samples. This easy to use package offers sophisticated analysis for both single and large-scale 2D comparison studies. Its design and functions address the needs of both experts and beginners and includes both automatic as well as interactive gel analysis.
Submitted Dec 03, 2000
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| Membrane Protein Secondary Structure Prediction Server
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The purpose of this server is to predict the transmembrane (TM) secondary structures of membrane proteins, using the method of preference functions. Scientific publications describing the method are listed at the bottom of this page. The method was invented by Davor Juretic , professor at the University of Split , Croatia. This server was written by Damir Zucic, at the University of Osijek , Croatia.
Submitted Dec 02, 2000
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| MEROPS Database
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The MEROPS database provides a wealth of information on proteases. There is a page describing each individual protease as well as one for each of the families into which they can be grouped, and even for each of the clans into which the families can be grouped. Many hundreds of proteases can be found by name, identifier or the organism in which they occur.
Submitted Dec 02, 2000
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| Module Pages
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The module pages contain information and research tools on mobile protein domains, developed, collected and maintained by the Bork group and various collaborators.
Submitted Dec 02, 2000
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| NCI Flicker
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Flicker is a method for comparing images from different Internet sources on your Web browser. The Flicker image viewer is a Java applet which reads two images from the Internet and then displays them in the your Web browser. It allows you to enhance them in various ways and to compare them visually in a third window called the flicker window.
Submitted Dec 03, 2000
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| NIMH-NCI Protein-Disease Database
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This server is part of the NIMH-NCI Protein-Disease Database project for correlating diseases with proteins observable in serum, CSF, urine and other common human body fluids based on biomedical literature.
Submitted Dec 03, 2000
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| Olfactory Receptor DataBase (ORDB)
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ORDB is a database of sequences of olfactory receptor proteins. It contains public and private sections which provide tools for investigators to analyze the functions of this very large gene family of G protein-coupled receptors. It also provides links to a local cluster of databases of related information, and to other relevant databases worldwide.
Submitted Dec 02, 2000
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| OWL Database
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The OWL database is a non-redundant protein sequence database produced from the following source databases: SWISSPROT Bairoch, A. & Boeckman, B. (1991); PIR(1-3) Sidman, K., George, D., Barker, W. * Hunt, L. (1988); GenBank translations Benson, D, Lipman, D., & Ostell, J. (1993); NRL-3D Pattabiraman N., Lowrey, A., Gaber, B., George,D.G. & Barker,W.C. (1989).
Submitted Jan 05, 2001
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| Phosphoprotein Database (PPDB)
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The purpose of a Phosphoprotein Database (PPDB) is to promote a systematic approach to the study of cellular protein phosphorylation. PPDBs have the potential to transform 2DE images from mere collections of spots on gels into images that convey information about cell lineage, the activation state of the cell, the ligands that the cell has encountered, the kinases, phosphatases and substrates present in the cell, and the activation state of these enzymes.
Submitted Dec 03, 2000
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| PRED-TMR
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PRED-TMR is a novel method that predicts transmembrane domains in proteins using solely information contained in the sequence itself. The algorithm refines a standard hydrophobicity analysis with a detection of potential termini ("edges", starts and ends) of transmembrane regions. This allows both to discard highly hydrophobic regions not delimited by clear start and end configurations and to confirm putative transmembrane segments not distinguishable by their hydrophobic composition.
Submitted Dec 02, 2000
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| ProClass Database
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The ProClass database is a non-redundant protein database organized according to family relationships as defined collectively by ProSite patterns and PIR superfamilies. The ProClass database can facilitate protein family information retrieval, unveil domain and family relationships, and classify multi-domained proteins, by combining global and motif similarities into a single family organization scheme.
Submitted Dec 02, 2000
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| Protein Information Resource
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The Protein Information Resource (PIR), in collaboration with the Munich Information Center for Protein Sequences (MIPS) and the Japanese International Protein Sequence Database (JIPID) maintains the PIR-International Protein Sequence Database --- a comprehensive, annotated, and non-redundant protein sequence database in which entries are classified into family groups and alignments of each group are available.
Submitted Sep 27, 2000
Updated Nov 05, 2000
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| Protein Kinase Resource
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The Protein Kinase Resource (PKR) is a web accessible compendium of information on the protein kinase family of enzymes. This resource includes tools for structural and computational analyses as well as links to related information maintained by others. The PKR is a collaborative project of protein kinase researchers and computational biologists working to create a database integrating molecular and cellular information.
Submitted Nov 23, 2000
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| Protein Mutant Database
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The Protein Mutant Database (PMD) covers natural as well as artificial mutants, including random and site-directed ones, for all proteins except members of the globin and immunoglobulin families. The PMD is based on literature, not on proteins. That is, each entry in the database corresponds to one article which may describe one, several or a number of protein mutants.
Submitted Sep 19, 2000
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| Protein Spotlight
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Protein Spotlight (ISSN 1424-4721) is a periodical electronic review from the SWISS-PROT group of the Swiss Institute of Bioinformatics (SIB). It is published on a monthly basis and consists of articles focused on particular proteins of interest. Each issue is available, free of charge, in HTML or PDF format.
Submitted Dec 02, 2000
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| Protein Topology
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This web site is devoted to protein structural topology and protein topology cartoons.
Submitted Dec 02, 2000
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| ProteoMetrics
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ProteoMetrics, LLC is a bioinformatics company that develops innovative software to rapidly identify and characterize proteins. The company developed out of an academic effort to more effectively utilize proteomic research and has now expanded into the commercial sector. Currently, a major focus of its activity is the development of an advanced intranet framework to support large-scale, high-throughput proteomics projects.
Submitted Dec 02, 2000
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| PSA Structure Prediction
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The Protein Sequence Analysis (PSA) server predicts protein secondary and tertiary structure based on sequence, and is available for researchers who have amino acid sequences for proteins of unknown structure and for which no homologous sequences are known. To use PSA, one submits a single amino acid sequence to the server, which may be instructed to analyze the sequence in one of three ways: using Type-1, Type-2, or WD-repeat DSMs. DSMs are Discrete State-space Models for patterns of alpha-helices, strands, tight turns, and loops in specific structural classes.
Submitted Dec 02, 2000
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| Sacch3D
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Sacch3D, an extension of the Saccharomyces Genome Database , presents structural information for every protein in the yeast genome. Here you can find text, graphics, and interactive 3D images to help you explore the structure and function of yeast proteins.
Submitted Dec 02, 2000
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| SANT Domain
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SANT domains are a epeated motif in N-CoR, the nuclear receptor co-repressor.
Submitted Dec 02, 2000
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| SIENA-2DPAGE
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Two-dimensional polyacrylamide gel electrophoresis database. You can search in SIENA-2DPAGE by description line (DE) or by ident (ID), by accession number (AC line), by clicking on a spot: select one of the reference maps, click on a spot and then get the corresponding information from the database, by author (RA lines), or get a list all entries.
Submitted Dec 03, 2000
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| Simon's Guide
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This web site is a database for the Eph family of receptor protein tyrosine kinases and their ligands, the ephrins. Much excitement regarding this new family results from their roles in developmental neurobiology as molecular guides for axons. However, they may be involved in many other processes; cancer, angiogenesis, haematopoiesis, and kidney development. The expression patterns of members in this family suggest that their functions during development and in the adult organism is still relatively unknown. It is salient that their name derives from the initial cloning, by Hirai in 1987, of the Eph receptor from an erythropoietin (hormone for the production of red blood cells) producing hepatocellular carcinoma cell line, which illustrates their potential importance in many
systems.
Submitted Dec 02, 2000
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| SOSUI Server
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Classification and Secondary Structure Prediction of Membrane Proteins.
Submitted Dec 02, 2000
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| SWISS-2DPAGE
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SWISS-2DPAGE contains data on proteins identified on various 2-D PAGE reference maps. You can locate these proteins on the 2-D PAGE maps or display the region of a 2-D PAGE map where one might expect to find a protein from SWISS-PROT.
Submitted Dec 03, 2000
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| The AAA Server
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This server is intended to help by displaying a phylogenetic tree of the AAA superfamily which, as a clickable map, provides easy access to some basic information, references and database links (including Medline links for the references) for all known AAA proteins (known to me, that is). For scientists with a non-graphical browser, a list of sequence names is provided. You can also search the AAA database for sequence names (including synonyms), host organisms, protein functions, or authors of papers about AAA members.
Submitted Dec 02, 2000
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| The Chaperonin
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The Chaperonin Home Page is designed to be a repository for information about the important class of heat shock proteins known as chaperonins. This page will provide vital information to all researchers in the field of heat shock proteins.
Submitted Dec 02, 2000
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| The Homeobox Page
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This page maintains information relevant to homeobox genes (in particular about classification/evolution).
Submitted Dec 02, 2000
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| The Intein Database
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Protein splicing is defined as the excision of an intervening protein sequence (the INTEIN) from a protein precursor and the concomitant ligation of the flanking protein fragments (the EXTEINS) to form a mature extein protein and the free intein (Perler 1994). Protein splicing results in a native peptide bond between the ligated exteins (Cooper 1993). Extein ligation differentiates protein splicing from other forms of autoproteolysis. Inteins are named with a 3 letter genus/species designation followed by the extein gene name. If more than 1 intein is present in an extein gene, the inteins are given a numerical suffix.
Submitted Dec 02, 2000
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| The Protein Structure Database (PSdb)
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The Protein Structure Database (PSdb), is a protein database, dervived from the information available in the Protein Databank and NRL-3D database, that relates secondary (e.g. Helix, Sheet, Turn, Random Coil) and tertiary information (e.g. Solvent accessibility, internal relative distances, and ligand interactions) to the primary structure.
Submitted Dec 02, 2000
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| The RCSB Protein Data Bank
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The single international repository for the processing and distribution of 3-D macromolecular structure data primarily determined experimentally by X-ray crystallography and NMR.
Submitted Sep 15, 2000
Updated Jan 05, 2001
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| The RNase P Database
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The RNase P Database is a compilation of RNase P sequences, sequence alignments, secondary structures, three-dimensional models, and accessory information.
Submitted Dec 02, 2000
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| The Thyroid Hormone Receptor Resource
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TRR provides a variety of information on TRs as well as more general information shared with other NHRR sites. It is anticipated that the TRR will publish general comments, essays and data that members of the scientific community would like to make generally available.
Submitted Dec 02, 2000
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| TMbase
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TMbase is a database of transmembrane proteins and their helical membrane- spanning domains. TMbase was originally meant as a tool for analyzing the properties of transmembrane proteins.
Submitted Dec 02, 2000
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| UCSF 2D PAGE
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This server presents information on proteins identified following isolation by two dimensional polyacrylamide gel electrophoresis (2D PAGE). The proteins have been rapidly identified through extensive use of the mass spectrometry based peptide sequencing power of the UCSF Mass Spectrometry Facility, directed by Professor Alma L. Burlingame in the Department of Pharmaceutical Chemistry at the University of California San Francisco (UCSF).
Submitted Dec 03, 2000
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| Yeast 2D-PAGE
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This is a 2D-PAGE protein database containing information about 2D-PAGE resolved proteins from a number of species of yeast, however, the main focus will be on Saccharomyces cerevisiae. The database will display information about the identity and expression profile of resolved proteins.
Submitted Dec 03, 2000
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| Yeast Protein Map from Bordeaux
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2D Gel Map of Saccharomyces cerevisiae proteins.
Submitted Dec 03, 2000
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